Meningococcal vaccine. From capsular polysaccharides of microbes to proteases

Cover Page
  • Authors: Alliluyev A.P., Anokhina I.V., Rumsh L.D., Melnikov E.E., Kotelnikova O.V., Sitnikova E.A., Drozzina E.J., Zhigis L.S., Yagudayeva E.J., Razgulyaeva O.A., Zueva V.S., Kozlov L.V., Avakov A.E.
  • Issue: No 4 (2012)
  • Pages: 16-22
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3627

Abstract


Microbial capsular polysaccharides for many years provided a highly practical public health vaccines for preventing meningococcal, pneumococcal and Haemophilus influenza infection, and typhoid fever. Their application in the form of conjugates with protein carriers eliminate the gap in protection against these infections in children under one year. Extremely promising turned out offered us a new generation of vaccines, which have synthetic peptides conjugated to a meningococcal polysaccharide. Thus, new approaches to the solution of the problem of meningococcal disease vaccination serogroup B were open. In recent years, Russian researchers first suggested to use IgA1 protease (one of the major virulence factors of microbes and almost identical for mentioned below infections) for prevention of such diseases as meningococcal of all serogroups, pneumococcus and hemophilia infections. Patented processes for producing of the vaccine define domestic priority of its production and use.

A P Alliluyev

People’s Friendship University

Email: rudnvestnik@yandex.ru
Faculty of Medicine

I V Anokhina

People’s Friendship University

Email: rudnvestnik@yandex.ru
Faculty of Medicine

L D Rumsh

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

E E Melnikov

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

O V Kotelnikova

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

E A Sitnikova

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

E J Drozzina

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

L S Zhigis

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

E J Yagudayeva

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

O A Razgulyaeva

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

V S Zueva

Institute of bioorganic chemistry n. a. M.M. Shemyakin and Yu. A. Ovchinnikov of the Russian Academy of Sciences

L V Kozlov

ederal budgetary institution of science Moscow Research Institute of Epidemiology and Microbiology n. a. G.N. Gabrichevskiy

A E Avakov

Ltd. “Bio-Diagnostics”

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Copyright (c) 2012 Аллилуев А.П., Анохина И.В., Румш Л.Д., Мельников Э.Э., Котельникова О.В., Ситникова Е.А., Дрожжина Е.Ю., Жигис Л.С., Ягудаева Е.Ю., Разгуляева О.А., Зуева В.С., Козлов Л.В., Аваков А.Э.

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