The importance of pharmacogenetic research for optimization of antihypertensive treatment

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Abstract


As time goes by, significant individuality of antihypertensive drugs effectiveness may be clarified by pharmacogenetic research methods. Pronounced variability of pharmacological response may be caused by mononucleotide substitutions in genes, coding biotransformation enzymes. The present work is dedicated to investigation of allelic variants of functionally defective genes CYP2D6 and CYP2C9 in patients with arterial hypertension. Possible relation of distinct associations of polymorphous gene variants with difference in individual sensitivity to beta-blockers and angiotensin receptor blockers was shown.

O V Shevchenko

Saratov State Medical University n.a. V.I. Razumovsky

Email: svistunv@mma.ru <mailto:svistunv@mma.ru>
Кафедра фармакологии; Саратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития Росздрава; Saratov State Medical University n.a. V.I. Razumovsky

E N Bychkov

Saratov State Medical University n.a. V.I. Razumovsky

Кафедра психиатрии и наркологии; Саратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития Росздрава; Saratov State Medical University n.a. V.I. Razumovsky

O M Posnenkova

Saratov Research Institute of Cardiology

Центр продвижения новых кардиологических информационных технологий; Саратовский НИИ кардиологии Минздравсоцразвития России; Saratov Research Institute of Cardiology

P Ya Dovgalevsky

Saratov Research Institute of Cardiology

Saratov Research Institute of Cardiology

S I Bogoslovskaya

Saratov State Medical University n.a. V.I. Razumovsky

Кафедра клинической фармакологии; Саратовский государственный медицинский университетим. В.И. Разумовского Минздравсоцразвития Росздрава; Saratov State Medical University n.a. V.I. Razumovsky

A A Svistunov

Research Institute of PharmacyFirst Moscow State Medical University n.a. M.I. Sechenov

Research Institute of PharmacyFirst Moscow State Medical University n.a. M.I. Sechenov

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Copyright (c) 2012 Шевченко О.В., Бычков Е.Н., Посненкова О.М., Довгалевский П.Я., Богословская С.И., Свистунов А.А.

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