HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN

Cover Page
  • Authors: Chumak AA1, Astrelina TA1, Yakovleva MV1, Lebedeva L.L.1, TV Pukhlikova LL1, Dishlevaya ZM2, Arkhipova AN2, Azova MM3
  • Affiliations:
    1. GBUZ “Stem cell bank”
    2. FSBI RCCH Health Ministry of Russia
    3. Peoples’ Friendship University of Russia
  • Issue: No 1 (2013)
  • Pages: 15-19
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3200
  • Cite item

Abstract


This study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of children with AAA, divided by gender and age. Our results revealed distinction in HLA-markers of predisposition and sustainability to AAA. Possible differences in factors of immunogenetic predisposition suggest different mechanisms involved in the development of the disease in different groups of children and reconsider the existing model of the pathogenesis of AAA.

About the authors

A A Chumak

GBUZ “Stem cell bank”

Email: crlpv@mail.ru
Department of Health of the City of Moscow HLA-typing laboratory

T A Astrelina

GBUZ “Stem cell bank”

Email: t_astrelina@mail.ru
Department of Health of the City of Moscow HLA-typing laboratory

M V Yakovleva

GBUZ “Stem cell bank”

Email: crlpv@mail.ru
Department of Health of the City of Moscow HLA-typing laboratory

Lidiya L'vovna Lebedeva

GBUZ “Stem cell bank”

Email: crlpv@mail.ru
Department of Health of the City of Moscow HLA-typing laboratory

L L TV Pukhlikova

GBUZ “Stem cell bank”

Email: crlpv@mail.ru
Department of Health of the City of Moscow HLA-typing laboratory

Z M Dishlevaya

FSBI RCCH Health Ministry of Russia

Email: dishleva@mail.ru
Department of Hematology № 1

A N Arkhipova

FSBI RCCH Health Ministry of Russia

Email: tan.120505@mail.ru
Department of Hematology № 1

M M Azova

Peoples’ Friendship University of Russia

Email: azovam@mail.ru
Department of Biology and General Genetics

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Copyright (c) 2013 Чумак А.А., Астрелина Т.А., Яковлева М.В., Лебедева Л.Л., Пухликова Т.В., Дышлевая З.М., Архипова А.Н., Азова М.М.

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