HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN

A A Chumak; Чумак Анна Александровна; T A Astrelina; Астрелина Татьяна Алексеевна; M V Yakovleva; Яковлева Мария Валерьевна; Lidiya L'vovna Lebedeva; Лебедева Лидия Львовна; L L TV Pukhlikova; Пухликова Татьяна Владимировна; Z M Dishlevaya; Дышлевая Зарема Михайловна; A N Arkhipova; Архипова Анастасия Николаевна; M M Azova; Азова Мадина Мухамедовна

HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN

Authors: Chumak AA¹, Astrelina TA¹, Yakovleva MV¹, Lebedeva L.L.¹, TV Pukhlikova LL¹, Dishlevaya ZM², Arkhipova AN², Azova MM³
Affiliations:
1. GBUZ “Stem cell bank”
2. FSBI RCCH Health Ministry of Russia
3. Peoples’ Friendship University of Russia
Issue: No 1 (2013)
Pages: 15-19
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3200

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Abstract

This study presents the genetic polymorphism of HLA-antigens in acquired aplastic anemia (AAA) in 147 children (85 boys и 62 girls) aged 1 to 18 with. The control group is consisted of 1700 umbilical cord blood samples of healthy newborns. The genetic polymorphism of HLA was studied in groups of children with AAA, divided by gender and age. Our results revealed distinction in HLA-markers of predisposition and sustainability to AAA. Possible differences in factors of immunogenetic predisposition suggest different mechanisms involved in the development of the disease in different groups of children and reconsider the existing model of the pathogenesis of AAA.

Keywords

HLA-antigens, acquired aplastic anemia, children

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Vol 29, No 1 (2025)

HE CHARACTERISTICS OF GENETIC POLYMORPHISM OF HLA-ANTIGENS IN ACQUIRED APLASTIC ANEMIA IN CHILDREN

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About the authors

A A Chumak

T A Astrelina

M V Yakovleva

Lidiya L'vovna Lebedeva

L L TV Pukhlikova

Z M Dishlevaya

A N Arkhipova

M M Azova

References

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