Influence isotopic composition of water on combined biological activity adjuvants na2edta and essential trace elements. Message 2

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  • Authors: Titorovich O.V., Pleteneva T.V., Uspenskaya E.V., Maksimova T.V., Lukashova M.S., Khodorovich N.A., Syroeshkin A.V., Burdeinaya T.N.
  • Issue: No 1 (2015)
  • Pages: 120-125
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3181

Abstract


Physico-chemical and biopharmaceutical analysis excipients and drug indicates the absence of the previously announced their inertia. Excipients can exhibit biological activity by themselves, and influence the activity of the active compound. Previously, we have shown that the water depleted in deuterium reduces the toxic effect of disodium ethylenediaminetetraacetate (Na 2EDTA). Disodium edetate is used as a stabilizer in liquid dosage forms including ointments, suppositories and tablets, is known as E386 preservative in the food industry. Zinc is as essential trace elements involved in many vital processes and is a part of the multi-component drugs. We have studied the combined toxicity of adjuvant Na 2EDTA and zinc salts in solutions with different ratios of isotopes of hydrogen (D/H) on biological models Spirotox.

O V Titorovich

Peoples’ Friendship University of Russia

Email: titorovicholga@gmail.com
Department of Pharmaceutical and Toxicological Chemistry

T V Pleteneva

Peoples’ Friendship University of Russia

Email: tvplet@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

E V Uspenskaya

Peoples’ Friendship University of Russia

Email: uspenskaya75@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

T V Maksimova

Peoples’ Friendship University of Russia

Email: maximtat@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

M S Lukashova

Peoples’ Friendship University of Russia

Email: maria_lukas@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

N A Khodorovich

Peoples’ Friendship University of Russia

Email: nkhodorovich@mail.ru
Department of General Pathology and Pathophysiology

A V Syroeshkin

Institute of Applied Geophysics

Email: livmatter@mail.ru

T N Burdeinaya

ZAO “Legkaya voda”

Email: t_burdeynaya@yahoo.com

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Copyright (c) 2015 Титорович О.В., Плетенева Т.В., Успенская Е.В., Максимова Т.В., Лукашова М.С., Ходорович Н.А., Сыроешкин А.В., Бурдейная Т.Н.

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