Influence isotopic composition of water on combined biological activity adjuvants na2edta and essential trace elements. Message 2

O V Titorovich; Титорович Ольга Валерьевна; T V Pleteneva; Плетенева Татьяна Вадимовна; E V Uspenskaya; Успенская Елена Валерьевна; T V Maksimova; Максимова Татьяна Владимировна; M S Lukashova; Лукашова Мария Сергеевна; N A Khodorovich; Ходорович Надежда Анатольевна; A V Syroeshkin; Сыроешкин Антон Владимирович; T N Burdeinaya; Бурдейная Татьяна Николаевна

Influence isotopic composition of water on combined biological activity adjuvants na2edta and essential trace elements. Message 2

Authors: Titorovich OV¹, Pleteneva TV¹, Uspenskaya EV¹, Maksimova TV¹, Lukashova MS¹, Khodorovich NA¹, Syroeshkin AV², Burdeinaya TN³
Affiliations:
1. Peoples’ Friendship University of Russia
2. Institute of Applied Geophysics
3. ZAO “Legkaya voda”
Issue: No 1 (2015)
Pages: 120-125
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3181

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Abstract

Physico-chemical and biopharmaceutical analysis excipients and drug indicates the absence of the previously announced their inertia. Excipients can exhibit biological activity by themselves, and influence the activity of the active compound. Previously, we have shown that the water depleted in deuterium reduces the toxic effect of disodium ethylenediaminetetraacetate (Na 2EDTA). Disodium edetate is used as a stabilizer in liquid dosage forms including ointments, suppositories and tablets, is known as E386 preservative in the food industry. Zinc is as essential trace elements involved in many vital processes and is a part of the multi-component drugs. We have studied the combined toxicity of adjuvant Na 2EDTA and zinc salts in solutions with different ratios of isotopes of hydrogen (D/H) on biological models Spirotox.

Keywords

Spirotox, excipients, biological activity, deuterium depleted water, Spirotox

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Vol 29, No 1 (2025)

Influence isotopic composition of water on combined biological activity adjuvants na2edta and essential trace elements. Message 2

Full Text

Abstract

Keywords

About the authors

O V Titorovich

T V Pleteneva

E V Uspenskaya

T V Maksimova

M S Lukashova

N A Khodorovich

A V Syroeshkin

T N Burdeinaya

References

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