The role of fetal proteins in the pathogenesis of development of brain edema in patients with ischemic stroke

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Abstract


The aim of the study was to determine the role of fetal proteins AFP, CEA, CA 19-9, CA 125, CA 15-3, CA 72-4, CYFRA 21-1 in the pathogenesis of the development of clinically significant brain edema in patients with ischemic stroke. It is established that the level of CA 15-3 had the statistical significance of the impact on the development of brain edema, OR was 1,058 (95%CI 1,011-1,107, p = 0.015). The threshold value of CA 15-3 for the development of brain edema was 21,0 (95%CI 18,7-23,3) IU/ml. Reference interval for CA 15-3 in this study was 6,53 of 22.2 IU/ml. Increasing of the level of CA 15-3 above the 90 th percentile of the reference interval was interrelated with the risk of brain edema. This can be explained by the participation of CA 15-3, located mainly on the epithelial cells, in intercellular interactions cells of the blood-brain barrier, the violation of which leads to the development of vasogenic brain edema.

A A Arkhipkin

LLC «Scientific center EFiS»

O V Lyang

Peoples’ Friendship University of Russia

Email: olyang84@gmail.com
Department of hospital therapy with the course of clinical laboratory diagnostics

A G Kochetov

Peoples’ Friendship University of Russia

Department of hospital therapy with the course of clinical laboratory diagnostics

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Copyright (c) 2014 Архипкин А.А., Лянг О.В., Кочетов А.Г.

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