Anticancer activity of a new pharmaceutical composition of diindolylmethane by inhibiting the cell viability in vitro

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Abstract


We have studied antitumor effects of a new pharmaceutical composition with improved bioavailability containing 3,3’-diindolylmethane (DIM) by in vitro modelling. Cytotoxicity of the test substance was determined by MTT assay. Pharmaceutical composition based on DIM inhibits the growth of tumor cell lines of endometrial cancer CRL-1622 (IC50 = 41,9 µM) and HTB-113 (IC50 = 52,2 µM). Results of the study allow to recommend the further investigation of antitumor activity in vivo .

V I Kiselev

Peoples' Friendship University of Russia

Email: ekazueva@yandex.ru. vkis10@mail.ru

V M Drukh

Peoples' Friendship University of Russia

Email: DruhVM@ilmixgroup.ru

O I Pchelintseva

Peoples' Friendship University of Russia

Email: pchelintseva87@mail.ru

I N Kuznetsov

Moscow State Medical Stomatological University (MGMSU) n.a. A.I. Evdokimov

Email: Kuznetsovin@ilmixgroup.ru

E L Muyzhnek

ZAO «MiraxBioPharma»

Email: MuyzhnekEL@ilmixgroup.ru

E A Gorbunova

Research Center for Obstetrics, Gynecology and Perinatology

Email: fiestagor@gmail.com

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Copyright (c) 2014 Киселев В.И., Друх В.М., Пчелинцева О.И., Кузнецов И.Н., Муйжнек Е.Л., Горбунова Е.А.

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