The influence of chemical analogs of decarboxylated ornithine and S-(adenosil)-methionine on the growth of L-cell tissue culture

Cover Page
  • Authors: Siatkin SP1, Berezov TT2, Fedoronchuk TV1, Gridina NY.1, Neborakh EA1, Shevkhun NA1, Sokueva NA1, Ustinova EV1, Sokuev RI1
  • Affiliations:
    1. Russian Peoples' Friendship University
  • Issue: No 4 (2010)
  • Pages: 26-31
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/2717
  • Cite item

Abstract


The effect of aliphatic amino- and oxy-derivatives of Ornithine and of S-(Adenosil)-methionine on the growth of L-cells in tissue culture was studied. The common known specific inhibitors of polyamines synthesis enzymes DFMO and MGBG were used for control and monitoring of test compounds action efficiency. The action of 1-aminooxy-3-aminopropan (APA), S-(5'-desoxyadenosile)-S-methyl-β-thioethyl-hydroxylamine (AMA) individually manner and in combination of one with another was similar with DFMO and MGBG effect but less pronounced. The degree of L-cell growth inhibition in the 4th day achieved 50-60%. By the 7th day there was observed a tendency not only to the growth rate stabilization but also to its reconstruction. It is indicative of reversible effect of APA and AMA compounds action on the cell growth that it differs from DFMO and MGBG actions.

About the authors

S P Siatkin

Russian Peoples' Friendship University

Email: syata@mail.ru <mailto:syata@mail.ru>
Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

T T Berezov

T V Fedoronchuk

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

N Ya Gridina

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

E A Neborakh

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

N A Shevkhun

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

N A Sokueva

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

E V Ustinova

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

R I Sokuev

Russian Peoples' Friendship University

Кафедра биохимии; Российский университет дружбы народов; Russian Peoples' Friendship University

References

Statistics

Views

Abstract - 68

PDF (Russian) - 58

Cited-By



Copyright (c) 2010 Сяткин С.П., Березов Т.Т., Федорончук Т.В., Гридина Н.Я., Неборак Е.А., Шевкун Н.А., Сокуева Н.А., Устинова Е.В., Сокуев Р.И.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies