New predictive factors determining the clinical flow of oral mucositis in patients with plane-cellar cancer of oropharyngeal region


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Abstract

Mucositis is a common and severe complication of cancer treatment. The use of herbal medicinal products in patients with malignant tumors of the oral mucosa and maxillofacial region can be considered as one of the promising methods for the prevention and treatment of mucositis. The effectiveness of local treatment of mucositis may be identified through evaluation of hemomicrocirculation in the mucous membrane of the oral cavity. In 2016-2017 years, we evaluated microcirculation parameter (MP) of the oral mucosa in four randomly selected points from 23 patients with squamous cell carcinoma of the oropharyngeal region subjected to radiation therapy in combination with the use of long-acting plant-based medications. The study was performed in the “Russian Scientific Center of Roentgenology and Radiology” of the Ministry of Health of the Russian Federation. The results confirm the efficiency of these drugs for the prevention and treatment of oral mucositis compared with the common methods of mouth irrigations with a decoction of chamomile and oleotherapy. Indicators of hemomicrocirculation in oral mucosa in patients with squamous cell carcinoma of the oropharyngeal region appeared to depend on the severity of the clinical manifestation of mucositis.

About the authors

A M Avanesov

Peoples’ Friendship University of Russia (RUDN)

Author for correspondence.
Email: avanesov_am@rudn.university.ru

E N Gvozdikova

Federal State Budgetary Institution Russian Scientific Center of Roentgenoradiology (RSCRR) of the Ministry of Health of the Russian Federation

Email: avanesov_am@rudn.university.ru

References

  1. Status of oncological assistance to the population of Russia in 2015. Ed. A.D. Caprin, V.V. Starinsky, G.V. Petrova. M., 2016. 236 p.
  2. Nuriyeva N.S. Peculiarities of prosthetics after surgical treatment of malignant tumors of the oropharyngeal zone. Ural Medical Journal. 2010. N 12. P. 105—108.
  3. Chissov V.I., Davydov M.I. Oncology. National leadership. Moscow: Geotar-Media. 2017. 576 p.
  4. Patrick J., Stiff M.D. The Challenges of Oral Mucositis and Its Therapy. J Support Oncol. 2004. N 2. P. 70—72.
  5. Nebert D.W., Wikvall, K., Miller W.L. Human cytochromes P450 in health and disease. Philos. Trans. R. Soc. Lond. B: Biol. Sci. 2013. V. 368. N 1. P. 2012—2431.
  6. Rosenthal D.I., Trotti A. Strategies for managing radiation-induced mucositis in head and neck cancer. Senin Radiat Oncol. 2009. N 19. P. 29—34.
  7. Campos M.I., Campos C.N., Aarestrup F.M., Aarestrup B.J. Oral mucositis in cancer treatment: natural history, prevention and treatment. Mol Clin Oncol. 2014. N 2. P. 337—340.
  8. Zhu G. et al. Asian expert recommendation on management of skin and mucosal effects of radiation, with or without the addition of cetuximab or chemotherapy, in treatment of head and neck squamous cell carcinoma. BMC Cancer. 2016. N 16. P. 24.
  9. Gvozdikova E.N., Avanesov A.M., Manuylov B.M. Features of the tactics of treatment of oral mucositis in cancer patients receiving combined treatment for squamous cell carcinoma of the oropharyngeal region. New in Dentistry. 2017. No. 5. P. 40—42.
  10. Mortensen H.R. et al. Factors associated with acute and late dysphagia in the DAHANCA 6&7 randomized trial with accelerated radiotherapy for head and neck cancer. Acta Oncol. 2013. N 52. P. 1535—1542.
  11. Vera Llonch M. et al. Oral mucositis in patients undergoing radiation treatment for head and neck carcinoma. Cancer. 2006. V. 106. P. 329—336.
  12. Gevorkov A.R. Basic principles of managing patients with mucositis and dermatitis in radiation treatment with drug modification of patients with squamous cell carcinoma of the oropharyngeal region. Tumors of the head and neck. 2016. N 3. C. 9—16.
  13. Gileva M.A., Gvozdeva L.M. Methods of treatment of chemotherapeutic lesions of the oral mucosa in children with acute leukemia. Russian Dental Journal. 2003. N 1. P. 30—33.
  14. Vasilyeva V.A., Kuzmina L.A., Klyasova G.A., Parovnikikova Ye.N. Experience of using calcium phosphate in patients after high-dose polychemotherapy and hematopoietic stem cell transplantation. Hematology and Transfusiology. 2012. N 3. P. 11—13.
  15. Wohlschlaeger A. Prevention and treatment of mucositis: a guide for nurses. J. Pediatr. Oncol. Nurs. 2004. V. 21. N 5. P. 281—287.
  16. Zlotow J.M., Berger A.M., Portenay R.K., Weissman D.E. Oral manifestations and complications of cancer therapy Principles and Practice of Palliative Care and Supportive Oncology. Philadelphia: Lippencoft Williams and Wilkins. 2002. P. 182—298.
  17. Budach V. Hyperfractionated accelerated chemoradiation with concurrent. Cancer. 2005. V. 103. N 6. P. 1165—1171.
  18. Bromek E., Wojcikowski J., Daniel W.A. Involvement of the paraventricular (PVN) and arcuate (ARC) nuclei ofthe hypothalamus in the central noradrenergic regulation of liver cytochrome P450. Biochem. Pharmacol. 2013. N 86. P. 1614—1620.

Copyright (c) 2018 Avanesov A.M., Gvozdikova E.N.

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