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Arterial hypertension (AH) is highlighted as a complication of bronchopulmonary dys-plasia (BPD) in children. The review provides information on the incidence, pathophysiology, diagnosis and treatment of AH in children with BPD. After analyzing the studies, were identified risk factors for hypertension in children with BPD, the role of endothelial dysfunction in raising systemic blood pressure, analyzed therapy and consequences of AH in children with BPD.

D Yu Ovsyannikov

Principal contact for editorial correspondence.
RUDN University Москва. 117198, Москва, ул. Миклухо-Маклая, 8

доктор медицинских наук, зав. каф. педиатрии Российского университета дружбы народов

A D Strutynskaya
Pirogov Russian National Research Medical University

M G Kantemirova
RUDN University Москва. 117198, Москва, ул. Миклухо-Маклая, 8

M A Karnaushkina
First Moscow State Medical University named after I.M. Sechenov, Moscow, RF

  • Neal W. A. & Adelman R. D. Neonatal hypertension. Pediatr Clin North Am 1978. V. 25. P. 99—110.
  • Flynn J. T. Neonatal hypertension: diagnosis and management. Pediatr Nephrol. 2000. V. 14. P. 332—341.
  • De Jong F., Monuteaux M. C., Van Elburg R. M., Gillman M. W. & Belfort M. B. Systematic review and meta-analysis of preterm birth and later systolic blood pressure. Hypertension. 2012. V. 59. N 2. Р. 226—234.
  • Ovsyannikov D. Yu., Antonov A. G., Ionov O. V., Ryndin A. Yu., Levadnaya A. V., & Iva¬nov D. O. Draft protocol on diagnosis, prevention and treatment of bronchopulmonary dys¬plasia. Neona-tology: news, opinions, training. 2014. V. 1. N 3. P. 161—175.
  • U.S. Department of Health and Human Services. The fourth report on the Diagnosis, Evaluation, and Treatment of High Blood Pressure in Children and Adolescents. Pediatrics. 2004. V. 114. N 2. Р. 555—576.
  • URL: (date of the application).
  • Abman S. H., Warady B. A., Lum G. M. & Koops B. L. Systemic hypertension in infants with bron-chopulmonary dysplasia. J Pediatr 1984. V. 104. P. 928—931.
  • Alagappan A. & Malloy M. H. Systemic hypertension in very low birth weight infants with bron-chopulmonary dysplasia: incidence and risk factors. Am J Perinatol. 1998. V. 15. P. 3—8.
  • Sehgal A., Malikiwi A., Paul E., Tan K. & Menahem S. Systemic arterial stiffness in infants with bronchopulmonary dysplasia: potential cause of systemic hypertension. J Perinatol. 2016. V. 1. P. 1—6.
  • Anderson A. H., Warady B. A., Daily D. K., Johnson J. A. & Thomas M. K. Systemic hyperten-sion in infants with severe bronchopulmonary dysplasia: associated clinical factors. Am J Perinatol 1993. V. 10. P. 190—193.
  • Jobe A. H., Bancalari E. Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 2001. V. 163. N 7. Р. 1723—1729.
  • Neptune E. R. Chronic obstructive pulmonary disease and bronchopulmonary dysplasia: Common mechanisms but distinct manifestations? Pediatric Allergy, Immunology, and Pulmonology. 2011. V. 24. N 2. Р. 119—125.
  • Clarenbach C. F., Senn O., Sievi N. A., Arnoldus G. C., Van Gestel G. R., Rossi G. A., Puhan M. A., Thurnheer R., Russi W. & Kohler M. Determinants of endothelial function in patients with COPD. Eur. Respir J. 2013. V. 42. P. 1194—1204.
  • Sinden N. J. Systemic inflammation and comorbidity in COPD: a result of ‘overspill’ of inflammatory mediators from the lungs? Review of the evidence. Thorax. 2010. V. 65. P. 930—936.
  • Romme Е., McAllister D. A., Murchison J. T., Van Beek E. J. R., Petrides G. S., Price C. O. S., Rut-ten E. P. A., Smeenk F., Wouters E. & MacNee W. Associations between COPD related manifestations: a cross-sectional study. Respiratory Research. 2013. V. 14. P. 129—136.
  • Boytsova E. V., Zapevalova E. Yu. & Ovsyannikov D. Yu. Respiratory, neurological and func¬tional consequences of bronchopulmonary dysplasia in children and adults. Neonatology: news, opinions, training. 2014. V. 1. P. 71—79.
  • Ovsyannikov D. Yu., Zaitseva N. O., Shokin A. A. & Degtyareva E. A. Complications of bron¬chopulmonary dysplasia: pulmonary hypertension and pulmonary heart. Neonatology: news, opin-ions, training. 2014. V. 2. Р. 38—48.
  • Ovsyannikov D. Yu., Degtyareva E. A., Zaitseva N. O. & Shokin A. A. Pulmonary hypertension and pulmonary heart in children with bronchopulmonary dysplasia: risk factors, diagnosis, treatment and prevention options. Pediatrics. 2013. V. 92. N 5. Р. 32—39.
  • Guyton A. K. & Hall D. E. Medical physiology. Trans. from the english; V.I. Kobrin Eds. Mos-cow: The Logosphere, 2008: 1296.
  • Dionne J. M., Abitbol C. L. & Flynn J. T. Hypertension in infancy: diagnosis, management and outcome. Pediatric nephrology. 2010 V. 27. N 1. P. 17—32.
  • Wells T. G., Bunchman T. E. & Kearns G. L. Treatment of neonatal hypertension with enalaprilat. J Pediatr. 1990. V. 117. P. 664—667.
  • Mason T., Polak M. J., Pyles L., Mullett M. & Swanke C. Treatment of neonatal renovascular hyper-tension with intravenous enalapril. Am J Perinatol. 1992. V. 9. P. 254—257.


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