Abstract
50 reproductive age women with oligomenorrhea in puberty and 15 women with normal menstrual cycle were examined. Objective examination and definition of prolactin, gonadotropic and thyrotropic hormones of hypophysis, cortisol, estradiol and progesterone were made. For the reason of the results pregravidary preparation program was advanced. This program included differentiated usage of estrogen-gestagen drugs and pure gestagen drugs. Such preparation leaded to decrease frequency of abortion risk and placental insufficiency, which were diagnosed by definition of decreasing choriogonadotropin β-subunit level in 11–12 weeks, unconjugated estriol and common choriogonadotropin level in 16–20 weeks, and, also, echographic signs.