The influence of electrical stimulation (es) of paleocerbellar cortex upon penicillin-induced foci induced in brain cortex of kindled rats

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Abstract

Electrical stimulation (ES) (0,25 ms, 100 Hz, 150-250 mcА) of paleocerebellar cortex (pyramis and culmen) caused the suppression of epileptogenic foci, induced in frontal cortex via application of penicillin solution (16 000 IU/ml) to male Wistar rats in three weeks from the moment of last corazol kindled administration. Antiepileptic effects have been pronounced in form of suppression of amplitude and frequency of spikes as well as in the net shortening of life-span of foci. Lower and higher intensities of ES did not cause suppression of focal epileptogenesis.

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L S Godlevsky

Odessa State Medical University

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский государственный медицинский университет; Odessa State Medical University

E V Kobolev

Odessa State Medical University

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский государственный медицинский университет; Odessa State Medical University

O G Ovchinnikova

Odessa State Medical University

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский государственный медицинский университет; Odessa State Medical University

V F Mustyatsa

G А Drozdova

'Peoples Friendship University of Russia <http://www.multitran.ru/c/m.exe?t=4557871_1_2>

Кафедра патологической физиологииМедицинский факультет; Российский университет дружбы народов; 'Peoples Friendship University of Russia

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Copyright (c) 2010 Годлевский Л.С., Коболев Е.В., Овчинникова О.Г., Мустяца В.Ф., Дроздова Г.А.

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