The effect of prednisolone on the NSE- and CD-68-positive cells of the spleen

The aim of our research was to study the effect of prednisolone on the quantitative and morphological characteristics of NSE+ and CD-68+ cells in different functional zones of the spleen. During the morphometrical research we set up five morphotypes of NSE+-cells and four morphotypes of CD-68+ cells. It showed that CD-68+ cells of II type and NSE+-cells (II and IV types) are more sensitive to prednisolone. We came to the conclusion that there is a probability of identity of subpopulations I NSE+ and 2 CD-68+, II NSE+ and 4 CD-68+, III NSE+ and 4 CD-68+ because they are characterised by identical morphological indicators in norm and in experiment.

spleen, prednisolone, neuron specific Enolase, NSE+-cells, CD-68+ cells