Impoliteness entails the employment of strategies oriented toward attacking face and bringing about social disruption. Although research on impoliteness has received great attention in the past two decades, how impolite utterances are perceived and what the recipients of impoliteness do in return has remained relatively under-addressed. The current study set out to examine native English and Persian speakers’ perceptions of and response to impoliteness in the production of the speech act of refusal. To this end, 90 native English speakers and 120 native Persian speakers were administered a written discourse completion task containing eight refusals that either observed politeness or contained various degrees of impoliteness. The results showed that native Persian speakers did not perceive any of the refusals to be impolite whereas three of the refusals were considered impolite by native English speakers. When reacting to impoliteness in refusals, native English speakers exploited a wider range of strategies than did Persian speakers. The results showed that social distance and power relations were of more significance for Persian speakers than for English speakers in perceiving the degree of impoliteness; however, in responding to an utterance perceived as impolite, English speakers were more likely to adopt offensive strategies to counter impoliteness, including positive and negative impoliteness strategies. These findings indicate both cross-cultural divergence and convergence in the perception of impoliteness and responses to impoliteness.