This paper problematises political satire in a time when the COVID-19 virus has provoked numerous deaths worldwide, and had dramatic effects on social behaviour, on a scale unknown in western nations since World War II. Most populations have endured ‘lockdown’, periods of enforced domestic imprisonment, which led to images of the empty streets of big cities appearing in media, symbols of the drastic changes that the health emergency was making necessary. Yet, from the outset, comic memes began to circulate across (social) media, while in mainstream print media political satirists continued to lampoon official responses to the ongoing crisis. The paper thus aims to explore the connection of political satire and humour, asking two principle research questions: firstly, how to explain the humorous effects of these multimodal artefacts in such depressing circumstances; secondly, from a pragmatic perspective, to account for their overall socio-political function.The study uses memes taken from various online sources (Facebook, Twitter, Google) during the crisis, analysed according to a mixed approach that blends notions from Humour studies, especially incongruity (Morreall 2016), with insights from linguistic pragmatics (e.g. Kecskes 2014). The findings emphasise the emotional dimension of this form of satire, as the memes work against the backdrop of a range of feelings (anger, bitterness, disappointment, frustration, despair, etc.), many of which have been widely generated by the COVID-19 crisis and political responses to it. In short, to paraphrase Walter Benjamin (2008: 378), man may ‘run out of tears but not of laughter’. The findings contribute to our understanding of online satire as an emergent genre, one that uses the affordances of new media to extend the social potentialities of a traditional subversive discourse form.