Polymorpnism and multifunctionality of blood group antigens

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Abstract


Group antigens of red blood cells are not only markers of blood groups, but also have different functions: receptor, transport, regulatory, trophic, immune, etc. The human genome has a gene locus ABO, which determines the blood group and regulates synthesis of the corresponding antigens. Genes A and B do not produce antigens directly, and their direct products are enzymes - glycosyltransferases. Transferases are able to attach the respective residues of glucose to the H-antigen galactose, thereby forming antigens A, B or AB. A and B antigens are heterogeneous in their structure and can be manifested in a number of different allotype. The main feature of the ABO system is the presence of natural antibodies to the missing red blood cell's antigen in plasma. In the interaction of antigen with antibody, both compounds exert mutual influence on their own conformation.

About the authors

E A Ryskina

Peoples' Friendship University of Russia

Email: dar31@mail.ru <mailto:dar31@mail.ru>
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; Peoples' Friendship University of Russia

N N Chernov

Peoples' Friendship University of Russia

Email: olya.k@mail.ru <mailto:olya.k@mail.ru>
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; Peoples' Friendship University of Russia

A A Epifanova

State Medical University of Samara

Email: dar31@mail.ru
Кафедра фундаментальной и клинической биохимии; Самарский ГМУ; State Medical University of Samara

N C Nefedova

State Medical University of Samara

Email: dar31@mail.ru <mailto:dar31@mail.ru>
Кафедра фундаментальной и клинической биохимии; Самарский ГМУ; State Medical University of Samara

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Copyright (c) 2011 Рыскина Е.А., Чернов Н.Н., Епифанова А.А., Нефедова Н.С.

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