Participation of cholinergic and adrenergic mechanisms in gastric reactions to exogenous serotonin infusion

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Abstract


This study is dedicated to investigation of serotoninergic structures that activate motility of the stomach. Experiments were performed on 94 Wistar rats under general anesthesia, mechanical ventilation, bilateral vagotomy and transection of both glossopharyngeal nerves. Mechanical activity of the stomach was recorded during serotonin adipanate infusion to intact animals and on the background of the ongoing actions of cholinergic and adrenergic antagonists. The blockade of adrenergic and cholinergic receptors does not prevent, but contrary, increase stimulatory effect of serotonin. β-adrenergic blockade increases the intensity of observed reactions almost up to 90%. Conclusion: both adrenergic and cholinergic mechanisms provide inhibitory pattern on serotoninergic structures that regulates motor function of the stomach.

V I Torshin

Russian Peoples' Friendship University

Email: orlovka@yahoo.com
Кафедра нормальной физиологииМедицинский факультет; Российский университет дружбы народов; Russian Peoples' Friendship University

V M Smirnov

Russian State Medical University

Email: orlovka@yahoo.com
Кафедра нормальной физиологии; Российский государственный медицинский университет; Russian State Medical University

D S Sveshnikov

Russian State Medical University

Email: orlovka@yahoo.com
Кафедра нормальной физиологии; Российский государственный медицинский университет; Russian State Medical University

A V Kuchuk

Russian State Medical University

Email: orlovka@yahoo.com <mailto:orlovka@yahoo.com>
Кафедра нормальной физиологии; Российский государственный медицинский университет; Russian State Medical University

I A Yurasova

Russian State Medical University

Email: orlovka@yahoo.com <mailto:orlovka@yahoo.com>
Кафедра нормальной физиологии; Российский государственный медицинский университет; Russian State Medical University

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Copyright (c) 2011 Торшин В.И., Смирнов В.М., Свешников Д.С., Кучук А.В., Юрасова И.А.

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