Evaluation of effectiveness of solvent-detergent viral in activation in the manufacture of intravenous human immunoglobulin G in a model of virus diarrhea — mucosal disease of cattle

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  • Authors: Kaz’yanin AV1, Zubkova NV2, Krasilnikov IV3, Lobastova AK3, Anastasiev VV2, Nikolaeva AM4, Glotova TI5, Kungurtseva OV5, Glotov AG5
  • Affiliations:
    1. Federal budgetary institute “Perm State Pharmaceutical Academy”
    2. FSUC “SIC Microgen” of MH RF Nizhniy-Novgorod Affiliate “ImBio”
    3. FSUC “SIC Microgen” of MH RF
    4. FSUC “SIC Microgen” of MH RF Perm Affiliate «Biomed»
    5. Institute of Experimentally Veterinary Medicine of Siberia and Far East
  • Issue: No 4 (2013)
  • Pages: 24-30
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3357
  • Cite item

Abstract


In model experiments using in vitro virus diarrhea — mucosal disease in cattle (bovine VD-MDC) studied the effectiveness of solvent-detergent (SD) virus inactivation used in the production of intravenous human immunoglobulin G (IgG). Optimized conditions for SD processing of immunoglobulin: the final concentration of tributylphosphate (TBP) 0.3% 0.2% sodium cholate, process temperature of 30 ± 1 °C to 36 ± 1 °C, incubation time 6 hours. The level of reduction of VD-MDC in the processing of the drug in these conditions was more than 6 log 10 TCD 50/ml.

About the authors

A V Kaz’yanin

Federal budgetary institute “Perm State Pharmaceutical Academy”

Email: a.kazyanin@mail.ru

N V Zubkova

FSUC “SIC Microgen” of MH RF Nizhniy-Novgorod Affiliate “ImBio”

Email: zubkova@imbio.ru

I V Krasilnikov

FSUC “SIC Microgen” of MH RF

Email: kiv06@mail.ru

A K Lobastova

FSUC “SIC Microgen” of MH RF

Email: a.k.lobastova@microgen.ru

V V Anastasiev

FSUC “SIC Microgen” of MH RF Nizhniy-Novgorod Affiliate “ImBio”

A M Nikolaeva

FSUC “SIC Microgen” of MH RF Perm Affiliate «Biomed»

Email: a.m.nikolaeva@mail.ru

T I Glotova

Institute of Experimentally Veterinary Medicine of Siberia and Far East

Email: t-glotova@mail.ru
Russian Academy of Agricultural Science

O V Kungurtseva

Institute of Experimentally Veterinary Medicine of Siberia and Far East

Email: k-olga-83@mail.ru
Russian Academy of Agricultural Science

A G Glotov

Institute of Experimentally Veterinary Medicine of Siberia and Far East

Email: glotov_vet@mail.ru
Russian Academy of Agricultural Science

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Copyright (c) 2013 Казьянин А.В., Зубкова Н.В., Красильников И.В., Лобастова А.К., Анастасиев В.В., Николаева А.М., Глотова Т.И., Кунгурцева О.В., Глотов А.Г.

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