Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu

Cover Page
  • Authors: Kuznetsova OM1, Berezov ТТ1, Chernov NN1, Nazarenko AY1, Kryuk Y.V1, Tereshkina IV2, Kushlinskii NE2
  • Affiliations:
    1. People's Friendship University of Russia
    2. Russian N.N. Blokhin Cancer Research Center
  • Issue: No 3 (2011)
  • Pages: 34-38
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3264
  • Cite item

Abstract


The comparative analysis of the quantity of matrix metalloproteinases (MMP) 2,7 and 9 in breast cancer is carried out; the concentration of sex hormones receptors and protein HER-2/neu are determined. Authentically high values MMP-2 and MMP-7 are found in a tumor tissue in contrast to the normal one. The elevated concentration of ММР-2 in a tumor is connected with receptor status (p < 0,05). The highest values of concentration ММР-7 and ММP- 9 are found at RE-, RP- and HER-2/neu + tumors, and also in the tumors with the size more than 4,0 cm.

About the authors

O M Kuznetsova

People's Friendship University of Russia

Email: olya.k@mail.ru
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

Т Т Berezov

People's Friendship University of Russia

Email: olya.k@mail.ru
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

N N Chernov

People's Friendship University of Russia

Email: olya.k@mail.ru
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

A Y Nazarenko

People's Friendship University of Russia

Email: olya.k@mail.ru
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

Yu V Kryuk

People's Friendship University of Russia

Email: olya.k@mail.ru
Кафедра биохимииМедицинский факультет; Российский университет дружбы народов; People's Friendship University of Russia

I V Tereshkina

Russian N.N. Blokhin Cancer Research Center

Email: olya.k@mail.ru
Лаборатория клинической биохимии; Российский онкологический научный центр им. Н.Н. Блохина РАМН; Russian N.N. Blokhin Cancer Research Center

N E Kushlinskii

Russian N.N. Blokhin Cancer Research Center

Email: olya.k@mail.ru
Лаборатория клинической биохимии; Российский онкологический научный центр им. Н.Н. Блохина РАМН; Russian N.N. Blokhin Cancer Research Center

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Copyright (c) 2011 Кузнецова О.М., Березов Т.Т., Чернов Н.Н., Назаренко А.Ю., Крюк Ю.В., Терешкина И.В., Кушлинский Н.Е.

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