Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu

O M Kuznetsova; Кузнецова Ольга Матвеевна; Т Т Berezov; Березов Темирболат Темболатович; N N Chernov; Чернов Николай Николаевич; A Y Nazarenko; Назаренко Анна Юрьевна; Yu V Kryuk; Крюк Юлия Васильевна; I V Tereshkina; Терешкина Ирина Владимировна; N E Kushlinskii; Кушлинский Николай Евгеньевич

Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu

Authors: Kuznetsova OM¹, Berezov ТТ¹, Chernov NN¹, Nazarenko AY¹, Kryuk Y.V¹, Tereshkina IV², Kushlinskii NE²
Affiliations:
1. People's Friendship University of Russia
2. Russian N.N. Blokhin Cancer Research Center
Issue: No 3 (2011)
Pages: 34-38
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3264

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Abstract

The comparative analysis of the quantity of matrix metalloproteinases (MMP) 2,7 and 9 in breast cancer is carried out; the concentration of sex hormones receptors and protein HER-2/neu are determined. Authentically high values MMP-2 and MMP-7 are found in a tumor tissue in contrast to the normal one. The elevated concentration of ММР-2 in a tumor is connected with receptor status (p < 0,05). The highest values of concentration ММР-7 and ММP- 9 are found at RE-, RP- and HER-2/neu + tumors, and also in the tumors with the size more than 4,0 cm.

Keywords

metalloproteinase, immunoenzyme method, breast cancer, HER-2/neu, receptors of sex hormones

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Matricsins 2, 7 and 9 in breast tumors. determination of posibile connection with the concentration of HER-2/neu

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Abstract

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About the authors

O M Kuznetsova

Т Т Berezov

N N Chernov

A Y Nazarenko

Yu V Kryuk

I V Tereshkina

N E Kushlinskii

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