Combined toxicity of Na 2EDTA and D 2O

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Abstract


Physicochemical and biopharmaceutical analysis of excipients doesn’t allow to characterize them as inert components of drug products. Excipients are known to exhibit their own biological activity as well as influence the activity of API and other components of the formulation (antioxidants, stabilizers, fillers, etc.). Combined biological activity of stabilizer/antioxidant — disodium ethylenediaminetetraacetate (Na 2EDTA) — and water with different ratios of hydrogen isotopes (D / H) was studied on biological models of Spirotox. It was found that with the growth of deuterium/protium ratio in water the toxicity of Na 2EDTA increased.

T N Burdeinaya

ZAO “Legkaya voda”

Email: t_burdeynaya@yahoo.com

O Y Zrelov

Peoples’ Friendship University of Russia

Email: zrelovoleg@rambler.ru
Department of Pharmaceutical and Toxicological Chemistry

T V Maksimova

Peoples’ Friendship University of Russia

Email: maximtat@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

M A Morozova

Peoples’ Friendship University of Russia

Email: gor-mariya@yandex.ru
Department of Pharmaceutical and Toxicological Chemistry

G I Mtei

Peoples’ Friendship University of Russia

Email: gastoi@yahoo.com
Department of Pharmaceutical and Toxicological Chemistry

E V Uspenskaya

Peoples’ Friendship University of Russia

Email: uspenskaya75@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

T V Pleteneva

Peoples’ Friendship University of Russia

Email: tvplet@mail.ru
Department of Pharmaceutical and Toxicological Chemistry

A V Syroeshkin

Institute of Applied Geophysics

Email: livmatter@mail.ru

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Copyright (c) 2013 Бурдейная Т.Н., Зрелов О.Ю., Максимова Т.В., Морозова М.А., Мтеи Г.И., Успенская Е.В., Плетенева Т.В., Сыроешкин А.В.

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