Immunogenetic markers for ulcerative colitis in adult population of moscow region

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Abstract


The article presents the results of the study of the genetic polymorphism of HLA-antigens in 65 adult patients with ulcerative colitis (UC) living in Moscow region. It was found that certain groups of HLA alleles are associated with the pathogenesis of UC. Immunogenetic factors of predisposition and sustainability to this disease depending on gender and age were revealed. The relationship of immunogenetic factors with clinical forms of the disease, course of the UC and response to therapy with glucocorticoids were shown.

D S Stavtsev

GBUZ “Blood transfusion station of the Department of Health of the City of Moscow”

Email: stavtsevd@mail.ru
HLA-typing laboratory

T A Astrelina

NIR FGBUN “Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology”

Email: t_astrelina@mail.ru
Sector of Implement Organization and Study of the Effectiveness

M M Azova

Peoples’ Friendship University of Russia

Email: azovam@mail.ru
Department of Biology and General Genetics

O A Mayorova

GBUZ “Blood transfusion station of the Department of Health of the City of Moscow”

Email: olgamai@mail.ru

V J Zinkin

GBUZ “Blood transfusion station of the Department of Health of the City of Moscow”

Email: ldip-su@yandex.ru

L L Lebedeva

GBUZ “Blood transfusion station of the Department of Health of the City of Moscow”

Email: lebedeval@list.ru

T V Pukhlikova

GBUZ “Blood transfusion station of the Department of Health of the City of Moscow”

Email: ptv-mos@mail.ru

A A Chumak

GBUZ “Blood transfusion station of the Department of Health of the City of Moscow”

Email: gella5@mail.ru

O V Knyazev

GBUZ Moscow Clinical Research Center

Biotherapy Laboratory of the Department of Bowel Pathology

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Copyright (c) 2014 Ставцев Д.С., Астрелина Т.А., Азова М.М., Майорова О.А., Зинкин В.Ю., Лебедева Л.Л., Пухликова Т.В., Чумак А.А., Князев О.В.

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