Clinical and diagnostic value of the determinantion of fractalkine in atopic dermatitis in children


Cite item

Full Text

Abstract

Atopic dermatitis belongs to the most common dermatoses observed in practice. In 2016 it was in 647 cases of atopic dermatitis (439,2 per 100 thousand population), while the main group of cases were children aged 0 to 14 years (64%). Aim. The aim of the study was to improve the diagnostics of allergic skin diseases in children. Materials and methods: the study included 135 children with atopic dermatitis and 29 children in the control group. Clinical and laboratory examination of patients was carried out in accordance with the standards of diagnosis of atopic dermatitis. Additionally, we determined the level fractalkine in blood serum using enzyme immunoassay kit for the quantitative determination fractalkine in biological fluids. Results. For children with atopic dermatitis regardless of clinical manifestations, characterized by elevated concentrations of fractalkine in blood serum depending on the duration of the process. Conclusions. Definition of fractalkine seems to be promising in the assessment of severity of dermatosis using it for monitoring and forecasting the further course of the process, and for assessing the effectiveness of therapeutic interventions.

About the authors

M M Ben

Astrakhan State Medical University

Author for correspondence.
Email: apteca-111a@mail.ru

E Ya Yanchevskaya

Astrakhan State Medical University

Email: apteca-111a@mail.ru

-

O A Mesnyankina

Astrakhan State Medical University

Email: apteca-111a@mail.ru

References

  1. Cheburkin A.V., Zaplatnikov A.L. Atopic dermatitis: clinical and pathogenetic variants and modern possibilities of topical immunomodulatory therapy. Russkij medicinskij zhurnal. 1998. 5:59—54.
  2. Batyrshina S.V., Haertdinova L.A., Halilova R.G., Sabynina E.E. Microbiocenosis skin of patients with atopic dermatitis and its correction. Prakticheskaja medicina. 2013. 1—4 (73): 33—37 (In Russ).
  3. Haertdinova L.A., Mingazova Je.N., Glushko N.I., Malanicheva T.G. Analysis of the structure of the skin microbiocenosis in children with atopic dermatitis. Kazanskij medicinskij zhurnal. 2005. 86 (6): 489—490 (In Russ).
  4. Kochergin N.G. Atopic dermatitis: modern aspects of pathogenesis and therapy. Russkij medicinskij zhurnal. 2004. 12 (18): 1076—1083 (In Russ).
  5. Kungurov N.V., Gerasimova N.M., Kohan M.M. Atopic dermatitis: types of flow, the principles of therapy. Ekaterinburg, 2000. 267 s. (In Russ).
  6. Malanicheva T.G., Salomykov D.V., Agafonova E.V. The state of phagocytic activity of neutrophils in atopic dermatitis in children complicated by mycotic infection. Allergologija i immunologija. 2003. 4:162—163. (In Russ).
  7. Melehina L.E., Bogdanova E.V. Prevalence of atopic dermatitis among children population of the Russian Federation in 2016. The proceedings of the XVII all-Russian Congress of dermatovenereologists and cosmetologists. Moscow, 2017.
  8. Logunov O.V., Bashkina O.A., Krasilova E.V. Evaluation of risk factors for complicated course of atopic dermatitis in children. Astrahanskij medicinskij zhurnal. 2011. T. 6. № 3. S. 185—187. (In Russ).
  9. Chong S., Lan H., Zeng K., Zhao X. Serum Fractalkine (CX3CL1) Concentration Correlates with Clinical Severity in Pediatric Atopic Dermatitis Patients. Ann. Clin. Lab. Sci. 2016. 46 (2): 168—73.
  10. Balabanian K., Foussat A., Dorfmuller P., Durand-Gasselin I., Capel F., Bouchet-Delbos L. et al. CX3C chemokine fractalkine in pulmonary arterial hypertension. Am. J. Respir. Crit. Care. Med. 2002. 165 (10): 1419—1425.
  11. Mesnyankina O.A., Janchevskaja E.Ju., Ben M.M. Fractalkine: pathogenic role and diagnostic capabilities. Kubanskij nauchnyj medicinskij vestnik. 2017. 2 (163): 148—151. (In Russ).
  12. Polunina E.A., Sevost'janova I.V., Voronina L.P., Polunina O.S., Mitrohina D.S. The relationship between enhanced level fractalkine and dysfunction of the vascular endothelium in chronic heart failure. Astrahanskij medicinskij zhurnal. 2014. 9( 2): 69—74. (In Russ).
  13. Sevost'janova I.V., Polunina O.S., Voronina L.P., Perova N.Ju., Beljakova I.S., Polunina E.A. The effect of cytokines with chemotactic properties on the vascular endothelium in bronchial asthma. Astrahanskij medicinskij zhurnal. 2014. 9(3): 56—62. (In Russ)
  14. Zhuravljova L.V., Lopina N.A. The level of fractalkan and its significance in predicting the presence and severity of atherosclerotic lesion of coronary vessels. Ukrainskij kardiologichesikj zhurnal. 2016. № 4. С. 62—67. (In Russ).
  15. Julia V., Staumont-Salle D., Dombrowicz D. Role of fractalkine/CX3CL1 and its receptor CX3CR1 in allergic diseases. Med Sci (Paris). 2016. 32 (30):260—266.
  16. Kim J., Kim J., Cho D., Park H. Molecular mechanisms of cutaneous inflammatory disorder atopic dermatitis. Int. J. of Molecular Sciences. 2016. 17 (8): 1234.
  17. Federal clinical recommendations. Dermatology 2015: diseases of the skin. Of sexually transmitted infections. M.: Delovoj jekspress, 2016. (In Russ)

Copyright (c) 2018 Ben M.M., Yanchevskaya E.Y., Mesnyankina O.A.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies