Эпигенетика и эпигенетические абберации при миоме матки

Обложка

Цитировать

Полный текст

Аннотация

В статье приведен краткий обзор основных современных направлений патогенеза миомы матки, отдельно выделена эпигенетика как самостоятельная наука, изложены наиболее изученные эпигенетические механизмы, произведена попытка оценить роль эпигенетики в патогенезе миомы матки, а также рассмотрены возможные перспективы изучения эпигенетических механизмов и применения в практике.

Об авторах

Фарида Мухарбиевна Есенеева

Российский университет дружбы народов

Email: eseneeva85@bk.ru

Всеволод Иванович Киселев

ФГБУ «Российский научный центр рентгенорадиологии»

Email: vkis10@mail.ru

Лейла Яшаровна Салимова

Городская клиническая больница им. В.М. Буянова

Email: leilasal@mail.ru

Список литературы

  1. Asada H., Yamagata Y., Taketani T. et al. Potential link between estrogen receptor-alpha gene hypomethylation and uterine fibroid formation. Mol. Hum. Reprod. 2008. Vol. 14. Iss. 9. P. 539-545.
  2. Cardozo E.R., Clark A.D. et al. The estimated annual cost of uterine leiomyomata in the United States of America. Obstetrics & Gynecology. 2012. P. 211.e1-211.e9.
  3. Carey N. The epigenetics revolution. How modern biology is rewriting our understanding of genetics, disease and inheritance. N. Carey. Phenix. 2012. Р. 349.
  4. Coddington C.C., Grow D.R., Ahmed M.S. et al. Gonadotropin-releasing hormone agonist pretreatment did not decrease postoperative adhesion formation after abdominal myomectomy in a randomized control trial. Fertility and Sterility. 2009. Vol. 91. Iss. 5. P. 1909-1913.
  5. Fujimota J., Hirose R., Ichigo S. et al. Expression of progesterone receptor form A and B mRNAs in uterine leiomyoma. Tumor Biology. 1998. Vol. 19. No. 2. P. 126-131.
  6. Gross K.L., Morton C.C. Genetics and the development of fibroids. Clinical Obstetrics and Gynecology. 2001. Vol. 44. P. 335-349.
  7. Guo X., Wang X.F. A mediator lost in the war on cancer. Cell. 2012. P. 927-929.
  8. Jichan N., Liu Xishi, Guo S.W. Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histonedeacetylase inhibitor and a demethylation agent. Reproductive Science. 2010. Vol. 17. Iss. 11. P. 995-1005.
  9. Kawakami T., Zhang C., Taniguchi T. et al. Characterization of loss-of-inactive X in Klinefelter syndrome and female-derived cancer cells. Oncogene. 2004. P. 6163-6169.
  10. Kim S., Xu X., Hecht A., Boyer T.G. Mediator is a transducer of Wnt/beta-catenin signaling. Biology and Chemistry. 2006. Vol. 281. P. 14066-14075.
  11. Kurachi O., Matsuo H., Samoto T. et al. Tumor necrosis factor- expression in human uterine leiomyoma and its down-regulation by progesterone. Journal of Clinical Endocrinology and Metabolism. 2001. Vol. 86. No. P. 2275-2280.
  12. Lian Li, Lee Kyoung-Mu, Han Wonshik et al. Estrogen and progesterone receptor status affect genome-wide DNA methylation profile in breast cancer. Human Molecular Genetics. 2010. Vol. 19. Iss. 2. P. 4273-4277.
  13. Luo X., Yin P., Reierstad S. et al. Progesterone and mifepristone regulate L-type amino acid transporter 2 and 4F2 heavy chain expression in uterine leiomyoma cells. J. Clin. Endocrinol. Metab. 2009. Vol. 94. Iss. 11. P. 4533-4539.
  14. Maekawa R., Sato Shun et al. Genome-Wide DNA Methylation Analysis Reveals a Potential Mechanism for the Pathogenesis and Development of Uterine Leiomyomas. PLOS. 2013. P. 1-13.
  15. Maruo T., Matsuo H., Samoto T. et al. Effects of progesterone on uterine leiomyoma growth and apoptosis. Steroids. 2000. P. 585-592.
  16. Masanori O., Yin Ping, Navarro Antonia et al. Inhibition of canonical WNT signaling attenuates human leiomyoma cell growth. Fertility and Sterility. 2014. Vol. 101. No. 5. P. 1441-1449.
  17. Markowski D., Helmke B.M., Belge G. et al. HMGA2 and p14Arf: major roles in cellular senescence of fibroids and therapeutic implications. Anticancer Research. 2011. Vol. 31. No. 3. P. 753-761.
  18. Mehine M. et al. Genomics of uterine leiomyomas: insights from high-throughput sequencing. Fertil. Steril. 2014. Vol. 5.
  19. Morelli C., Garofalo C., Bartucci M. et al. Estrogen receptor-alpha regulates the degradation of insulin receptor substrates 1 and 2 in breast cancer cells. Oncogene. 2003. P. 4007-4016.
  20. Radzinsky V.E., Totchiev G.F. Мyoma: course on organsaving treatment. Informational bulletin. Status Praesens. 2014. P. 24.
  21. Shun, S. Potential mechanisms of aberrant DNA hypomethylation on the x chromosome in uterine leiomyoma / Shun Sato, Ryo Maekawa et al. // Journal of Reproduction and Development. 2014. Vol. 60. No. 1. P. 47-54.
  22. Tseng Y.H., Butte A.J., Kokkotou E. et al. Prediction of preadipocyte differentiation by gene expression reveals role of insulin receptor substrates and necdin. National Cell Biology. 2005. P. 601-611.
  23. Qiwei Y., Aymara Mas, P. Michael Diamond et al. The Mechanism and Function of Epigenetics in Uterine Leiomyoma Development. Reproductive Sciences. 2015. P. 1-13.
  24. Yamagata Y., Maekawa R., Asada H. et al. Aberrant DNA methylation status in human uterine leiomyoma. Molecular Human Reproduction. 2009. P. 259-267.
  25. Ying Z., Weiyuan Z. Dual actions of progesterone on uterine leiomyoma correlate with the ratio of progesterone receptor A: B. Gynecological Endocrinology. 2009. Vol. 25. No. 8. P. 520-523.

© Есенеева Ф.М., Киселев В.И., Салимова Л.Я., 2016

Creative Commons License
Эта статья доступна по лицензии Creative Commons Attribution 4.0 International License.

Данный сайт использует cookie-файлы

Продолжая использовать наш сайт, вы даете согласие на обработку файлов cookie, которые обеспечивают правильную работу сайта.

О куки-файлах