Participation of various populations lymphocytes in formation of protection from meningococcosis

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Abstract

Immunization of mice by synthetic peptides fragments of meningococcus external membrane fibers caused the expressed protection of animals against infection caused by live virulent meningococcus culture serogroup A, B and C. There are leading part T-lymphocytes in protection of mice from this infection here. The analysis of T-cellular populations by means of a method flowing cytophluorometrics has shown increase CD4+ and CD8+ lymphocytes without change of parity CD4+/CD8+. The increase in number of these lymphocytes occurred in late terms after immunization of mice.

About the authors

O V Kotelnikova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Email: ovkot.2003@mail.ru <mailto:ovkot.2003@mail.ru>
Лаборатория синтетических вакцин; ИБХ им. М.М. Шемякина и Ю.А. Овчинникова РАН; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

E J Drozzina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Лаборатория синтетических вакцин; ИБХ им. М.М. Шемякина и Ю.А. Овчинникова РАН; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

O M Volpina

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Лаборатория синтетических вакцин; ИБХ им. М.М. Шемякина и Ю.А. Овчинникова РАН; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

D O Koroev

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Лаборатория синтетических вакцин; ИБХ им. М.М. Шемякина и Ю.А. Овчинникова РАН; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

M P Filatova

Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

Лаборатория синтетических вакцин; ИБХ им. М.М. Шемякина и Ю.А. Овчинникова РАН; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS

A P Alliluev

Peoples' Friendship University of Russia

Кафедра микробиологииМедицинский факультет; Российский университет дружбы народов; Peoples' Friendship University of Russia

References


Copyright (c) 2010 Котельникова О.В., Дрожжина Е.Ю., Вольпина О.М., Короев Д.О., Филатова М.П., Аллилуев А.П.

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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