Changes of blastogenic response of lymphoid cells in kindled animals under the influence of pentoxiphyllin

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Abstract

Under condition of acute experiments on male Wistar rats it was shown that under condition of kindling formation induced via repeated subthreshold corazol administration (30,0 mg/kg, i.p.) the decreasing of blastogenic response induced by bacterial lypopolysaccharide and phytogemagglutinin was shown. This effect was detectable after 10-th convulsant injection and intensified in the course of kindling (21 injections of picrotoxin). Pentoxiphyllin (25,0 and 50,0 mg/kg, i.p.) caused antiseizure effects and effectively prevented kindling-induced decreasing of blastogenic response in dose-depended manner.

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Е V Kobolev

Odessa State Medical University

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский госмедуниверситет; Odessa State Medical University

V V Desyatsky

Odessa State Medical University

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский госмедуниверситет; Odessa State Medical University

L S Godlevsky

Odessa State Medical University

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский госмедуниверситет; Odessa State Medical University

V F Mustyatsu

Peoples' Friendship University of Russia

Кафедра патологической физиологииМедицинский факультет; Российский университет дружбы народов; Peoples' Friendship University of Russia

G А Drozdova

Peoples' Friendship University of Russia

Кафедра биофизики, информатики и медицинской аппаратуры; Одесский госмедуниверситет; Peoples' Friendship University of Russia

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Copyright (c) 2010 Коболев Е.В., Десятский В.В., Годлевский Л.С., Мустяца В.Ф., Дроздова Г.А.

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