Anticancer activity of a new pharmaceutical composition of diindolylmethane by inhibiting the cell viability in vitro

V I Kiselev; Киселев Всеволод Иванович; V M Drukh; Друх Вадим Михайлович; O I Pchelintseva; Пчелинцева Ольга Игоревна; I N Kuznetsov; Кузнецов Игорь Николаевич; E L Muyzhnek; Муйжнек Екатерина Леонидовна; E A Gorbunova; Горбунова Елена Алексеевна

Anticancer activity of a new pharmaceutical composition of diindolylmethane by inhibiting the cell viability in vitro

Authors: Kiselev VI¹, Drukh VM¹, Pchelintseva OI¹, Kuznetsov IN², Muyzhnek EL³, Gorbunova EA⁴
Affiliations:
1. Peoples' Friendship University of Russia
2. Moscow State Medical Stomatological University (MGMSU) n.a. A.I. Evdokimov
3. ZAO «MiraxBioPharma»
4. Research Center for Obstetrics, Gynecology and Perinatology
Issue: No 2 (2014)
Pages: 95-101
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/2864

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Abstract

We have studied antitumor effects of a new pharmaceutical composition with improved bioavailability containing 3,3’-diindolylmethane (DIM) by in vitro modelling. Cytotoxicity of the test substance was determined by MTT assay. Pharmaceutical composition based on DIM inhibits the growth of tumor cell lines of endometrial cancer CRL-1622 (IC50 = 41,9 µM) and HTB-113 (IC50 = 52,2 µM). Results of the study allow to recommend the further investigation of antitumor activity in vivo .