Development of structure and technology of wound healthing gel

O A Semkina; Семкина Ольга Александровна; I P Smirnova; Смирнова Ирина Павловна; M A Dzhavakhyan; Джавахян Марина Аркадьевна; O V Bondarenko; Бондаренко Ольга Владимировна; L M Kishmakhova; Кишмахова Лидия Муратовна

Development of structure and technology of wound healthing gel

Authors: Semkina OA¹, Smirnova IP¹, Dzhavakhyan MA², Bondarenko OV², Kishmakhova LM¹
Affiliations:
1. Peoples’ Friendship University of Russia
2. All-Russian Institute of Medicinal and Aromatic Plants
Issue: No 4 (2013)
Pages: 79-87
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3365

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Abstract

Carbopol (974 P) was selected as the structure former to make a gel with L-lysine-alpha oxidase. Stability of the gel developed was studied with the use of physico-chemical, rheological and microbiological methods of analysis for the following indicators: the appearance of the gel, odor, pH, uniformity, colloid stability. The authenticity of the activity of L-lysine-a-oxidase in the gel, the viscosity of the gel and microbiological purity of the project comply with manufacturer's monograph L-Lysine-a-oxidase gel, 1% concentration. Studied the specific activity of the developed gel in animal experiments. The results of this study suggest a high wound-healing activity of gel with extract of L-lysine alpha-oxidase of 1%.

Keywords

Carbopol, soft dosage form, L-lysine-a-oxidase, culture medium, Trichoderm, gel technology, a hydrophilic ointment base, Carbopol

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

Development of structure and technology of wound healthing gel

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Abstract

Keywords

About the authors

O A Semkina

I P Smirnova

M A Dzhavakhyan

O V Bondarenko

L M Kishmakhova

References

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