The level of c-type natriuretic peptide in patients with respiratory cardial comorbidity, depending on genotypes of the gene of endothelial nitric oxide synthase

O S Polunina; Полунина Ольга Сергеевна; A Kh Akhmineeva; Ахминеева Азиза Халиловна; I V Sevostyanova; Севостьянова Ирина Викторовна; L P Voronina; Воронина Людмила Петровна

The level of c-type natriuretic peptide in patients with respiratory cardial comorbidity, depending on genotypes of the gene of endothelial nitric oxide synthase

Authors: Polunina OS¹, Akhmineeva AK.¹, Sevostyanova IV¹, Voronina LP¹
Affiliations:
1. Astrakhan State Medical Academy
Issue: No 4 (2013)
Pages: 52-57
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3361

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Abstract

In this work we have studied the level of C-type natriuretic peptide in patients with respiratory cardiac comorbidities (COPD + HD, COPD + IHD), depending on the genotypes (4a/4b and 4b/4b) of the gene of endothelial nitric oxide synthase. Investigation revealed the influence of VNTR-polymorphism on the level of CNUP under the comorbidity combination of COPD + HD, significantly increased production of CNUP, compared with a single disease. At the same time, in patients with COPD + IHD combination of 4а/4b has no significant effect on CNUP production, which is comparable with a single disease (COPD, IHD).

Keywords

C-type natriuretic peptide, endothelial dysfunction, chronic obstructive pulmonary disease, hypertension, ischemic heart disease

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Vol 29, No 1 (2025)

The level of c-type natriuretic peptide in patients with respiratory cardial comorbidity, depending on genotypes of the gene of endothelial nitric oxide synthase

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Abstract

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About the authors

O S Polunina

A Kh Akhmineeva

I V Sevostyanova

L P Voronina

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