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CLINICAL AND DIAGNOSTIC VALUE OF THE DETERMINANTION OF FRACTALKINE IN ATOPIC DERMATITIS OF CHILDREN
- Authors: Ben MM1, Yanchevskaya EY.1, Mesnyankina OA1
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Affiliations:
- Astrakhan State Medical University
- Issue: Vol 22, No 3 (2018)
- Pages: 308-313
- Section: ALLERGOLOGY. DERMATOLOGY
- URL: https://journals.rudn.ru/medicine/article/view/19683
- DOI: https://doi.org/10.22363/2313-0245-2018-22-3-308-313
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Abstract
In recent years there has been an increase in the incidence of atopic dermatitis in children. However, despite numerous studies, still remains the problem of objective laboratory diagnosis of this disease, and, respectively, rational pharmacotherapy. Aim. The aim of the study was to improve the diagnostics of allergic skin diseases in children. Materials and methods: the study included 135 children with atopic dermatitis and 29 children in the control group. Clinical and laboratory examination of patients was carried out in accordance with the standards of diagnosis of atopic dermatitis. Additionally, we determined the level fractalkine in blood serum using enzyme immunoassay kit for the quantitative determination fractalkine in biological fluids. Results. For most patients with Ad were a characteristic increase in the level fractalkine in blood serum depending on the severity of the disease. The highest concentrations of the studied CC chemokine is characteristic of severe process. Conclusions. Definition fractalkine in the serum can be used as an indicator of the severity of the pathological process and predicting its future course.
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About the authors
M M Ben
Astrakhan State Medical University
Author for correspondence.
Email: apteca-111a@mail.ru
E Ya Yanchevskaya
Astrakhan State Medical University
Email: apteca-111a@mail.ru
O A Mesnyankina
Astrakhan State Medical University
Email: apteca-111a@mail.ru
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