The study is dedicated to the main guidelines of the foreign policy of the State of Israel in the context of the current transformation of the world order. Before the start of the special military operation, despite a fairly strong strategic alliance with the United States, Israel pursued a pragmatic foreign policy and maintained mutually beneficial bilateral relations with the leading powers of the non-Western world - especially Russia, China and India. However, the sharp escalation of the situation in the Palestinian territories in October 2023 put Israel in front of an existential choice under the conditions of the emerging new bipolarity, and this choice was made in favor of the United States and its NATO allies. Now the official rhetoric in Israel has become consonant with the one that prevailed during the period of the severed relations between Russia and Israel. Nevertheless, in formulating policies where Russian and Israeli positions do not coincide, both sides continue to coordinate all actions within the framework of a joint dialogue. The article focuses on the main issues on which Russia and Israel differ: Ukrainian, Iranian, and Palestinian factors. China and India occupy a special place among Israel’s foreign policy priorities. The importance of these countries for the Jewish state will be increasing due to the inevitable isolationist tendencies in the region, which are growing against the backdrop of the worsening Israeli-Palestinian conflict. The article examines the main trends in Israel’s relations with some Arab countries, China and India.