Asia is now a central part of world politics, where the interests of a number of global and regional actors have collided, including India, China, Japan, the United States and Russia. With the collapse of the socialist bloc and the end of the Cold War, the U.S. embarked on a new security policy, changed its priorities, promoting a new balance of power and defining a new role for itself in the post-bipolar world. India, on the other hand, has strengthened its position in the Asian region thanks to its rapid economic growth, huge domestic market, modernization of armed forces, and practice of democratization. Given India’s transformation and the strategic importance of the Indian Ocean and its maritime transport routes, Washington has become interested in strengthening ties with New Delhi. As a result, India - U.S. relations are moving from the estrangement of the past to the strategic engagement of the present. Since 2004, when the document entitled “Next Step towards Strategic Partnership” was adopted, the two countries have been experiencing a phase of deep strategic convergence. This is particularly true in the area of security and defense. In the present study the author argues that Indo-US defense agreements stimulate India’s offensive power, while negatively affecting regional security in South Asia and especially Pakistan’s security. In the milieu of research methodology, the author uses the methods of content analysis, event analysis, and problem-chronological method.