The hybrid nature and scope of contemporary conflicts, the terrorism threat, and the dramatic increase in competition for resources, global militarization and security challenges in Africa do not only carry the risk of state collapse, but have conditioned concerted efforts by national, regional and international actors to protect human rights and remedy the humanitarian situation. In many ways, the African continent with its unique and diverse nature of conflicts has become a platform for the renewal of the United Nations (UN) peacekeeping through the development of new operational and normative practices and strategies that, as a distinctive feature of the UN missions in the African continent, have gradually moved from the status of innovations to the category of quite commonplace global practice. This article attempts to assess UN peacekeeping in Africa from the 1960s till 2022. The authors examine the characteristics, nature and scope of peacekeeping operations (PKOs) as well as strategies for transforming peacekeeping mandates. Using a problem-chronological approach, comparative analysis and quantitative assessments of the UN peacekeeping missions, the formats of cooperation with regional organizations (the African Union (AU) and the Economic Community of West African States (ECOWAS)), gender composition of the UN missions, in particular, the authors come to the natural conclusion that the number of the UN peacekeeping operations and political missions in Africa remains high and their mandates have expanded and become more complex with increased activity of the leading world powers. The authors conclude that stabilization and conflict resolution in Africa will greatly depend on effective cooperation between the UN and regional organizations, as well as on the UN reforms and its ability to adapt rapidly to changing conflict scenarios in each African state.