The mechanism of action of thymus-derived polypeptide (t-activin) in experimental emotional stress model: a neurochemical study

N M Kiseleva; Киселева Нина Михайловна; A V Novoseletskaya; Новоселецкая Анна Владимировна; A N Inozemtsev; Иноземцев Анатолий Николаевич; V S Kudrin; Кудрин Владимир Сергеевич; P M Klodt; Клодт Петр Михайлович; V B Narkevich; Наркевич Виктор Борисович; I V Zimina; Зимина Ирина Владимировна; V Ya Arion; Арион Виталий Яковлевич

The mechanism of action of thymus-derived polypeptide (t-activin) in experimental emotional stress model: a neurochemical study

Authors: Kiseleva NM¹, Novoseletskaya AV², Inozemtsev AN², Kudrin VS³, Klodt PM³, Narkevich VB³, Zimina IV⁴, Arion VY.⁴
Affiliations:
1. Russian State Medical University
2. Moscow State University n.a. M.V. Lomonosov
3. State Institute of Pharmacology n.a. V.V. Zakusov
4. FPI Scientific Research Institute for Physical-Chemical Medicine FMBA
Issue: No 4 (2011)
Pages: 143-148
Section: Articles
URL: https://journals.rudn.ru/medicine/article/view/3580

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Abstract

The effects of T-activin, the thymus-derived polypeptide, on the content level of monoamines and their metabolites in frontal cerebral cortex, striatum, hypothalamus, nucleus accumbens and hippocampus of rats under emotional stress conditions using HPLC technique have been studied. The substance was shown to reduce the indices of emotional tension and to improve adaptation in stressful conditions at rats that may be the evidence of the anxiolytic action of T-activin. It may be suggested that the positive influence of the thymus polypeptide manifested on the serotonin/norepinehrine balance in favor of the first in hypothalamus and frontal cerebral cortex.

Keywords

T-activin, serotonin, norepinephrine, stress, frontal cortex, hypothalamus

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Vol 28, No 3 (2024): PHYSIOLOGY. EXPERIMENTAL PHYSIOLOGY

The mechanism of action of thymus-derived polypeptide (t-activin) in experimental emotional stress model: a neurochemical study

Full Text

Abstract

Keywords

About the authors

N M Kiseleva

A V Novoseletskaya

A N Inozemtsev

V S Kudrin

P M Klodt

V B Narkevich

I V Zimina

V Ya Arion

References

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