CASPASE-3 and CASPASE-8 activity in right ventricular myocardial cells in experimental arterial hypertension

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  • Authors: Azova MM1, Blagonravov ML1, Frolov VA2
  • Affiliations:
    1. Peoples' Friendship University of Russia
    2. Peoples' Friendship University of RussiaMiklukho-Maklay str., 8, Moscow, Russia, 117198
  • Issue: No 4 (2011)
  • Pages: 44-47
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/3559
  • Cite item

Abstract


Caspase-3 and caspase-8 activity in right ventricular myocardial cells of rabbits with experimental arterial hypertension (AH) was investigated. Caspase-3 activity significantly increased at 2 and 4 weeks after modeling of AH. Obtained data demonstrated increased apoptosis in right ventricular myocardial cells in experimental arterial hypertension. Absence of significant increasing of caspase-8 activity indicates the predominance of intrinsic apoptogenic signals.

About the authors

M M Azova

Peoples' Friendship University of Russia

Email: azovam@mail.ru <mailto:azovam@mail.ru>
Кафедра биологии и общей генетики; Российский университет дружбы народов; Peoples' Friendship University of Russia

M L Blagonravov

Peoples' Friendship University of Russia

Email: victorfro@rambler.ru <mailto:victorfro@rambler.ru>
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of Russia

V A Frolov

Peoples' Friendship University of RussiaMiklukho-Maklay str., 8, Moscow, Russia, 117198

Email: victorfro@rambler.ru <mailto:victorfro@rambler.ru>
Кафедра общей патологии и патологической физиологии; Российский университет дружбы народов; Peoples' Friendship University of RussiaMiklukho-Maklay str., 8, Moscow, Russia, 117198

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Copyright (c) 2011 Азова М.М., Благонравов М.Л., Фролов В.А.

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