Claudin-1 and Ki-67 expression in oral leukoplakia and oral squamous cell carcinoma

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Abstract


The correlation was investigated between the level of cell proliferation and the intensity of claudin-1 expression in oral Leukoplakia with different grade of cell neoplastic transformation (according to WHO classification 2005, - SIN - Squamous Intraepithelial Neoplasia) and in oral Squamous cell carcinoma. Claudin-1 expression and cell proliferation were assessed using immunohistochemistry in different epithelial layers of oral mucosa. The inverse correlation was revealed between the level of cell proliferation and the intensity of claudin-1 expression in oral Leukoplakia and oral Squamous cell carcinoma.

A A Katushkina

Peoples' Friendship University of Russia

Кафедра патологической анатомии; Российский университет дружбы народов; Peoples' Friendship University of Russia

V A Koviazin

Peoples' Friendship University of Russia

Кафедра патологической анатомии; Российский университет дружбы народов; Peoples' Friendship University of Russia

I I Babichenko

Peoples' Friendship University of Russia

Кафедра патологической анатомии; Российский университет дружбы народов; Peoples' Friendship University of Russia

A S Grigorian

Central Research Institute for Stomatology

Лаборатория патологической анатомии; ФГУ «ЦНИИС и ЧЛХ Росмедтехнологий»; Central Research Institute for Stomatology

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Copyright (c) 2010 Катушкина А.А., Ковязин В.А., Бабиченко И.И., Григорьян А.С.

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