Value biomarker diagnosis and prediction of acute renal damage in patients with acute coronary syndromes without ST-segment elevation

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Abstract


Aim: to study the prognostic value of biomarkers (urine neutrophil gelatinase-associated lipocalin (uNGAL), urine interleukin-18 (uIL-18), serum cystatin C (sCysC), serum N-terminal prohormone of brain natriuretic peptide (sNT-proBNP) depending on the acute kidney injury (AKI) in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS). 58 patients with NSTE-ACS were examined. Patients with NSTE-ACS and early AKI had higher sCysC, sNT-proBNP, uNGAL and uIL-18 levels than the patients without AKI. No relationship between biomarkers and in-hospital mortality was revealed in patients with cardiorenal syndrome (CRS). AKI — acute kidney injury NSTE-ACS — non-ST-elevation acute coronary syndrome CRS — cardiorenal syndrome NT-proBNP — N-terminal prohormone of Brain Natriuretic Peptide IL-18 — interleukin-18 NGAL — neutrophil gelatinase-associated lipocalin

S Vladimirovna Avdoshina

Peoples’ Friendship University of Russia

Email: susya@kmail.ru
Department of Propaedeutics of Internal Diseases

S Vadimovna Villevalde

Peoples’ Friendship University of Russia

Email: villevaldes@mail.ru
Department of Propaedeutics of Internal Diseases

M Alekseevna Efremovtseva

Peoples’ Friendship University of Russia

Email: marinaef56@mail.ru
Department of Propaedeutics of Internal Diseases

Zh Davidovna Kobalava

Peoples’ Friendship University of Russia

Email: zkovbala@mail.ru
Department of Propaedeutics of Internal Diseases

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Copyright (c) 2013 Авдошина С.В., Виллевальде С.В., Ефремовцева М.А., Кобалава Ж.Д.

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