Directed search of hypoglycemic compounds in the series of aroylpyruvic acid derivatives

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Abstract


The article deals with synthesis of new oxovanadium metal complexes in the series of esters and arylamides of aroylpyruvic acids. Comparative estimation of hypoglycemic activity of original ligands and obtained chelates is conducted. The introduction of oxovanadium into molecule is found to potentiate sugar-reducing activity.

N A Pulina

Perm State Pharmaceutical Academy

Кафедра фармакологии, клинической фармакологии; Пермская государственная фармацевтическая академия; Perm State Pharmaceutical Academy

T A Yushkova

Perm State Pharmaceutical Academy

Кафедра фармакологии, клинической фармакологии; Пермская государственная фармацевтическая академия; Perm State Pharmaceutical Academy

A I Krasnova

Perm State Pharmaceutical Academy

Кафедра фармакологии, клинической фармакологии; Пермская государственная фармацевтическая академия; Perm State Pharmaceutical Academy

V V Yushkov

Perm State Pharmaceutical Academy

Кафедра фармакологии, клинической фармакологии; Пермская государственная фармацевтическая академия; Perm State Pharmaceutical Academy

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Copyright (c) 2010 Пулина Н.А., Юшкова Т.А., Краснова А.И., Юшков В.В.

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