Cytokine regulation of immune response against bacterial and viral co-infection of gut, caused by h. pylori and herpesviridae

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  • Authors: Nelyubin VN1, Mudrov VP1, Chekanov AV2, Sepiashvili RI3
  • Affiliations:
    1. Central Hospital No. 6 of the Russian Railways JSC
    2. Russian State Medical University
    3. Institute of Immunophisiology
  • Issue: No 2 (2011)
  • Pages: 41-46
  • Section: Articles
  • URL: http://journals.rudn.ru/medicine/article/view/2390
  • Cite item

Abstract


104 patients with the inflammatory diseases of stomach and duodenum were investigated. Levels of the IL-1β, IL-2, IFN-γ in blood serum were detected by ELISA. For detection of Helicobacter pylori (H. pylori) and Herpes viridae in biopsies from the zone of inflammation polymerase chain reaction (PCR) was used. Expression of mRNA cytokines: Il-1β, Il-2, Il-4, Il-6, Il-10, Il-18, IFN-γ, TNF-α in biopsies from 37 patients was detected by real time PCR. Results of biopsies revealed high frequency of detection of pathogenic strains of H. pylori (80%) and Herpes viridae (EBV, HHV-6, HHV-7, HHV-8) in various combinations. The increased levels of IL-1β, IL-2, IFN-γ in serum and of mRNA cytokines in infected mucous membrane were observed.

About the authors

V N Nelyubin

Central Hospital No. 6 of the Russian Railways JSC

Email: vlnelyubin@mail.ru <mailto:vlnelyubin@mail.ru>
Central Hospital No. 6 of the Russian Railways JSC

V P Mudrov

Central Hospital No. 6 of the Russian Railways JSC

Email: vlnelyubin@mail.ru <mailto:vlnelyubin@mail.ru>
Central Hospital No. 6 of the Russian Railways JSC

A V Chekanov

Russian State Medical University

Email: vlnelyubin@mail.ru <mailto:vlnelyubin@mail.ru>
Russian State Medical University

R I Sepiashvili

Institute of Immunophisiology

Email: vlnelyubin@mail.ru <mailto:vlnelyubin@mail.ru>
Institute of Immunophisiology

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Copyright (c) 2011 Нелюбин В.Н., Мудров В.П., Чеканов А.В., Сепиашвили Р.И.

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