Разнообразие механизмов аллерген-специфической иммунотерапии

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Аллергенспецифическая иммунотерапия (АСИТ) широко используется с целью обеспечения адекватного иммунного ответа, и в настоящее время это единственный вид терапии, модифицирующий патологический процесс. Существуют различные способы введения аллергена, включая подкожно, сублингвально, внутрилимфатически, накожно, интрадермально, перорально и интраназально. Несмотря на то, что оптимальный путь введения зависит от типа аллергена, некоторые пациенты остаются невосприимчивыми, и поэтому важно прогнозировать результат до и во время лечения. Следовательно, существует необходимость в выявлении потенциальных прогностических маркеров для иммунотерапии аллергенами. В обзоре обсуждаются резулбтаты современных исследований молекулярных механизмов АСИТ.

Об авторах

Лацин Цевертас

Университет Бурса Улудаг

Автор, ответственный за переписку.
Email: akdism@siaf.uzh.ch
Бурса, Турция

Акдис Мубацел

Цюрихский университет

Email: akdism@siaf.uzh.ch
Давос, Швейцария

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© Цевертас Л., Мубацел А., 2019

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