Development and functional significance of the pulmonary surfactant system

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Relevance. Prevention of the development of postoperative acute respiratory distress syndrome during operations on the descending thoracic aorta increases the effectiveness of therapy. The study of damage to the surfactant complex during ischemia and reperfusion of the lungs is relevant, since it involves the prophylactic use of the surfactant preparation during operations on the descending part of the thoracic aorta, which are characterized by a high risk of postoperative acute respiratory distress syndrome. Objective: to increase the effectiveness of pharmacological and respiratory therapy of acute respiratory distress syndrome, as well as to identify the role of the surfactant system of the lungs in the onset of inflammation against the background of tuberculosis and the development of regeneration mechanisms that affect the course and outcome of the disease. Materials and Methods. The study involved 24 people, including 14 volunteer patients with a diagnosed respiratory disease in an acute course (while the whole group received the drug from the study as an additional therapy). The sample of 14 people was formed solely due to the compliance of these patients with the criteria that were established before the start of the study of the drug, which had postoperative acute respiratory distress syndrome of various origins in their diagnosis. Results and Discussion. For a comprehensive laboratory determination, an algorithm was used that corresponded to the state standard to identify postoperative acute respiratory distress syndrome. For each participant in the experiments, it was proposed to develop a plan of treatment procedures, taking into account individualization and standardization. Conclusion. Some of the resulting data are collected with respect to the surfactant pulmonary system, which is presented in a compactor model format. A number of basic components are reflected here, which are classified according to cellular and non-cellular factors. At the same time, the surfactant substance helps to reduce the pronounced swelling, which can significantly reduce the process of «sticking» of the alveolar structures during inhalation. All this added up to the normal system of gas metabolism in the lung structures, including the control of the mucociliary system, which acts as a natural stimulator of the function of alveolar macrophages.

About the authors

Ruslan K. Shakhbanov

Dagestan State Medical University

Author for correspondence.
ORCID iD: 0000-0002-3573-2434
Makhachkala, Russian Federation

Madina N. Asadulaeva

Dagestan State Medical University

ORCID iD: 0000-0002-9006-0992
Makhachkala, Russian Federation

Saidat N. Alieva

Dagestan State Medical University

ORCID iD: 0000-0001-6824-2274
Makhachkala, Russian Federation

Alima A. Alimkhanova

Dagestan State Medical University

ORCID iD: 0000-0002-1651-0369
Makhachkala, Russian Federation


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Copyright (c) 2021 Shakhbanov R.K., Asadulaeva M.N., Alieva S.N., Alimkhanova A.A.

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