The paper investigates trade and investment relations between India and its two major trading partners, viz. the U.S. and China in the 2000-2010s. On the basis of mixed method research with equal use of quantitative and qualitative, as well as historical and statistical methods, the authors estimate the possibilities for expanding interstate interactions and the difficulties the countries might face. By comparing the scale and particulars of the product structure of Indo-American and Indo-Chinese trade, the authors reveal that intra-industry trade between India and the United States is at a fairly high level, which, in turn, is not typical for the trade between India and China, which is mostly inter-industry due to the sluggish cooperation of Indian and Chinese entrepreneurs. The authors assess the intensity of the Indo-American and Indo-Chinese bilateral trade between 2000-2018 by means of indices of intensity of India’s exports and imports to / from the USA and China, as well as indices of intensity of exports and imports of its partners to / from India. The obtained results outline the upward trend of the share of Indian exports to the U.S. relative to other countries, which indicates that India is successfully conquering the U.S. market, and Indian goods are becoming increasingly competitive. Meanwhile, the volume of Indian-Chinese trade remains on a much lower level than it could be expected with the current share of India in the world trade. In the meantime, neither for the United States nor for China, India is a dominant partner. The article also investigates major obstacles hindering the development of both Indo-American and Indo-Chinese bilateral relations. The obtained results enable the authors to predict that in the short- and mid-term economic cooperation between India and its leading partners is likely to strengthen, with India keeping striving for standing neuter while building the two most crucial vectors of its foreign economic policy.