The article reveals and comparatively analyses the peculiarities of the state-church relations in Russia and Egypt. Currently, the role of religion and religious institutions in world politics is actively increasing, as well as the process of secularization of public life is being redefined. Religion still often becomes the cause of discrimination, persecution of certain groups of society; the level of Islamophobia in Western countries and Religiophobia in the whole world is not decreasing. In these conditions, the importance of state-church relations within key international actors is also growing. The purpose of the study is to provide comparative analysis of the specifics of the state religion policy of Russia and Egypt in order to develop recommendations for the use of Russian religious institutions to strengthen Russia’s position in the Middle East. Russia and Egypt were chosen as research objects, since these countries have a rich history of interaction in the religious sphere, which could become a basis for the future cooperation between religious institutions of the two countries. In addition, Egypt is one of the key states in the Middle East, where Russian influence has never been dominant, but where exactly religious organizations such as the Russian Orthodox Church (ROC) most actively and successfully pursued Russia’s interests. Methodologically, the article is based on historical and empirical institutionalism, as well as comparative analysis and historical-genetic method. The study is quite novel, as it identifies four models of interaction between religious communities, which are based on two criteria: a) presence of religious institutions representing the interests of a particular community; b) status of religion in the state (dominant / minority religion). The practical significance of the study lies in its attempt to make recommendations for improving the use of religious organizations in Russia to promote state interests in Egypt on the basis of the highlighted features of state-church relations in Egypt.