The influence of catalaza gene polymorphism on the development of cardiovascular pathology in chronic obstructive pulmonary disease

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Abstract


Distribution analysis of alleles and genotypes of polymorphic markers C-262T catalaza gene in 90 patients with chronic obstructive pulmonary disease (COPD) in connection with presence and character of attendant cardiovascular pathology was made. Detection of polymorphic gene locus was made by polymerase chain reaction. Significant differences in genotypes frequency in patients with COPD and ischemic heart disease (IHD) and without it were discovered. Sstatistically significant increase of genotype CC frequency (relation of possibilities 5,13 p = 0,01) in COPD patients with IHD showed the increased risk of such pathology in CC genotype carriers. Among COPD patients with genotype CC higher indicators of malonate dialdehyde and lower catalaza level in blood serum were detected.

T A Uklistaya

SBEI HPE «Astrakhan state medical academy» MHPSD RF

Email: Uklistaya.Tatyana@yandex.ru
Department of internal diseases of pediatric faculty

G T Guseinov

SBEI HPE «Astrakhan state medical academy» MHPSD RF

Email: scorpionsg@rambler.ru
Department of internal diseases of pediatric faculty

O S Polunina

SBEI HPE «Astrakhan state medical academy» MHPSD RF

Department of internal diseases of pediatric faculty

H M Galimzyanov

SBEI HPE «Astrakhan state medical academy» MHPSD RF

Email: Uklistaya.Tatyana@yandex.ru
Department of infectious diseases

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Copyright (c) 2012 Уклистая Т.А., Гусейнов Г.Т., Полунина О.С., Галимзянов Х.М.

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