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ALPHA-FETOPROTEIN AS ANTI-AGING AGENT: EFFECT ON SURVIVAL AND AGE-MARKERS IN MICE
- Authors: Dontsov VI1, Krut’ko VN1, Chizhov AY.2
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Affiliations:
- Laboratory of Systems Analysis and Information Technologies in Medicine and Ecology, Federal Research Center«Informatics and Management» of the Russian Academy of Sciences
- Peoples’ Friendship University of Russia
- Issue: No 2 (2016)
- Pages: 110-117
- Section: Articles
- URL: https://journals.rudn.ru/ecology/article/view/12910
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Abstract
Alpha-fetoprotein is one of the best known embriospecific proteins, which is used to diagnose fetal abnormalities and tumor processes of the gastrointestinal tract and liver and has a pronounced immunotropic and detoxifying effect, and also a direct apoptotic effect on tumor cells. The appointment of AFP mice at the oldest age in our experiments, dramatically increased survival and markedly increased the relative weight immunotropic bodies, apparently, due to the characteristic of the AFP general effect of improving the functions of tissues and detoxifying action. Thus, AFP has a significant bioactivity and anti-aging effectname, that allows to consider it as a candidate for a geroprotective agent.
About the authors
V I Dontsov
Laboratory of Systems Analysis and Information Technologies in Medicine and Ecology, Federal Research Center«Informatics and Management» of the Russian Academy of Sciences
V N Krut’ko
Laboratory of Systems Analysis and Information Technologies in Medicine and Ecology, Federal Research Center«Informatics and Management» of the Russian Academy of Sciences
A Ya Chizhov
Peoples’ Friendship University of RussiaEcological faculty
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