Since the second half of the 20th century the Turkish-Israeli relations have developed in an uneven and unstable manner. Depending on the current situation in the conflict-torn Middle East, these relations tended to normalize, or descended into mutual hostility. During the 21st century, we could observe several rounds of confrontation and cooperation between the two states. Thus, the events of 2010 (the Freedom Flotilla incident) and 2017 (the transfer of the capital of Israel to Jerusalem) finally led to a rupture in relations between the two countries. A new round of stabilization has been marked since March 2022 and is associated with the visit of the President of Israel to Ankara at the invitation of the Turkish President R.T. Erdogan. The authors of the article see this step as the beginning of the process of finding agreements on achieving stability in relations between the countries of the Middle East region. The article attempts to analyze the evolution of the modern Turkish-Israeli cooperation, taking into account the patterns of their development since Türkiye has recognized the state of Israel. Using a comparative historical approach, the authors analyze the political problems of the modern bilateral relations, and consider the impact of such factors as the Arab-Israeli conflict, the Iranian nuclear program, the consequences of the “Arab Spring,” the foreign policy activities of the US Democratic and Republican administrations in the Middle East region, as well as the crisis over the status of Jerusalem. The authors underline that despite the pragmatic character of Türkiye’s foreign policy, any tension caused by the Palestinian issue will have an impact on Turkish-Israeli relations, which in turn might start a new round of conflict between the two sides. The authors have concluded that Turkish-Israeli relations are characterized by instability, which depends largely on the current balance of power in the Middle East region. It is obvious that the normalization of Turkish-Israeli interaction is a positive factor for the intensification of integration processes in the Middle East region as a whole.