The article analyses the US influence on Israeli policy towards both China and India. The United States has had and still has a significant influence on the dynamics of Israeli-Chinese and Israeli-Indian relations. The relevance of the issue stems from the growing importance of China and India in the world affairs amid rising tensions between the US and China that are spilling into a trade war. The article aims to explore the US influence on Israel’s policy in Asia. It examines the way how the Israeli leadership has adapted to Washington’s influence while promoting its strategic cooperation with China and India. The study comprises historical method, comparative analysis and historical-systematic analysis. The author comes to the following conclusions. First, Washington’s influence on Sino-Israeli relations has gone through five development stages: the first stage (1971-1989): implicit US support for the development of Sino-Israeli relations; the second stage (1990-1998): American criticism of military and technical cooperation between Israel and China; the third stage (1999-2005): Washington’s shift from criticism to pressure policy in order to prevent the Israeli leadership from military cooperation with China; the fourth stage (2006-2016): Israel’s acceptance of US demands and refusal to supply arms to Beijing (with Tel Aviv focusing on the development of trade and economic relations with China); the fifth stage (2017 - present): U.S. criticism of Israeli-Chinese economic cooperation amid worsening contacts between Beijing and Washington. The Israeli government is trying to meet Washington’s demands as well as preserve its strategic economic relations with Beijing. Second, the US factor, on the contrary, contributed to normalization of Indian-Israeli relations, having a positive impact on the development of trade, economic and military cooperation between Tel Aviv and New Delhi. Third, the US actions can be explained by an attempt to preserve its national interests. At the same time, the author stresses that the US influence on Israel’s policy in Asia complies with Washington’s regional priorities set forth in the 2017 US National Security Strategy.