This article examines the current state of nuclear power in the Middle East. The construction of nuclear power plants is closely related to the issues of energy security in the region. The necessity and prerequisites for diversification of the energy balance in the countries of the region, as well as the need for a reliable source of electricity, which will completely solve the problem of growing demand, are analyzed. The authors analyze the role of the Russian Federation in the development of nuclear energy in the Middle East and assess the prospects in the market of services in this sector, consider cooperation in the nuclear sector with all states of the region, identify the advantages and prospects of Russia’s possible participation in the implementation of nuclear power plant construction projects in the Middle East. The most promising direction for the development of nuclear energy today is the use of fast neutron technology and a closed cycle that allows the processing of spent nuclear fuel. The possession of such technologies has a significant potential for export and international cooperation and is a significant technological advantage of Russia. Rosatom group has competitive advantages in the market of nuclear technologies, including in the Middle East, as it has competencies in all parts of the production and technological chain of nuclear energy. The Russian Federation participates in many projects related to the construction of nuclear power plants and related infrastructure and plays a significant role in the development of nuclear energy in the Middle East, cooperates with all countries in the region that are promising for cooperation in this direction, having intergovernmental agreements, which include the construction of nuclear power plants with such States as Egypt, Jordan, Iran, UAE, Turkey, Saudi Arabia, and memorandums of cooperation with Bahrain, Qatar, Kuwait, Oman.