The need to study the Kyrgyz-Kazakh, Kyrgyz-Uzbek, Kyrgyz-Tajik interstate relations caused by the fact that there is a need to identify the cooperation framework in fuel and energy field. It is clear that Central Asian states were interdependent, but each individually played a role in the development of fuel and energy sector of Kyrgyzstan. Republic in bilateral relations with the neighboring countries of the region determines ways to improve the development of the fuel and energy complex, taking into account the issues of sovereignty and national interests. Kyrgyzstan, located in the neighborhood with these republics, does not use this advantage, but finds alternative partners. The main purpose of the study determines the role of Kazakhstan, Uzbekistan, Tajikistan in the energy sector of Kyrgyzstan. The processes of globalization affect relations between countries activating them and giving more interdependence of the states. The author emphasizes the importance of bilateral integration relations in the fuel and energy sectors of Central Asian countries. The necessity to build a high-quality format of political agreements with neighboring countries to prevent bilateral issues and implementation of promising projects in the sector, which can improve not only the economic development of Kyrgyzstan, but the entire Central Asian region is discussed. The study used historical and inductive analysis methods.