The article is devoted to the consideration of the moral factor in international relations. The author considers the issue of ethical evaluation of the responsibility of the actors of international relations in the ideas of a number of foreign and Russian thinkers of the 20th and 21st centuries. The author notes that the process of analysis of the ethics of responsibility in the framework of socio-political thoughts, as well as the mechanism of the impact of morality on international relations gives reasons to conclude that it is possible and necessary to specify the concept of “responsibility ethics”, which can be interpreted as “ethics of political responsibility” in the sphere of international relations and foreign policy. Thus, in the author’s point of view in the system of international relations there has emerged the most important category, which researchers characterize as the “ethics of political responsibility”. Relying on the idea of the Russian political scientist A.S. Kapto that the core of the “ethics of political responsibility” is a synthesis of political and moral responsibility, the author analyzes its structure and classification. The author comes to the conclusion that it is necessary to form the universal aspect of political responsibility among the actors of international relations.